GB 31604.54-2023 National food safety standard - Food contact materials and products - Determination of migration of bisphenol F and S (English Version)
GB 31604.54-2023 National food safety standard - Food contact materials and products - Determination of migration of bisphenol F and S
1 Scope
This standard specifies the determination of bisphenol F and bisphenol S migration in food contact materials and articles by LC method and LC-MS-MS method.
Method I - LC method applies to the determination of bisphenol F and bisphenol S migration in food contact plastic materials and articles, food contact paints and coatings, food contact paper and paperboard materials and food contact articles.
Method II - LC-MS-MS method applies to the determination of bisphenol F and bisphenol S migration in food contact materials and articles.
Method I LC method
2 Principle
Determine food contact materials and articles by LC method after migration test according to GB 31604.1 and GB 5009.156, inject the water-based, acidic and alcoholic food simulants directly after being filtered. Dry 95% (volume fraction) ethanol with nitrogen, scale with ethanol-water and inject the sample after filtering. Extract oil-like food simulants by methanol-water mixture, filter it and then inject. Dry the isooctane chemical alternative solvent with nitrogen, scale with methanol and water, filter it and then inject. Fix the quantity by external standard method.
3 Reagents and materials
Unless otherwise specified, all reagents used for this method are chromatographically pure, and the water is Class I water specified in GB/T 6682.
3.1 Reagents
3.1.1 Water-based, acid, alcoholic and oil-like food simulants and chemical alternative solvents: the reagents used comply with GB 5009.156.
3.1.2 n-hexane (C6H14)
3.1.3 Methanol (CH4O)
3.1.4 Acetonitrile (C2H3N)
3.1.5 Isooctane (C8H18)
3.1.3 Acetone (C3H6O)
3.1.7 Ethanol(C2H6O)
3.1.8 Corn oil: chemically pure, complying with GB 5009.156.
3.2 Preparation of reagents
3.2.1 Water-based, acidic and alcoholic, corn oil food simulants and chemical alternative solvents: prepared according to GB 5009.156.
3.2.2 Methanol-water mixture (1+1): measure 100mL ethanol and 100mL water, and mix well.
3.2.3 Ethanol-water mixture (1+1): measure 100mL ethanol and 100mL water, and mix well.
3.3 Standard
3.3.1 Bisphenol F (C13H12O2,CAS: 620-92-8): purity ≥99%, or standard certified by the state and granted a standard substance certificate.
3.3.2 Bisphenol S (C12H10O4, CAS: 80-09-1): purity ≥99%, or standard certified by the state and granted a standard substance certificate.
3.4 Preparation of standard solution
3.4.1 Standard stock solution
3.4.1.1 Bisphenol F (Bisphenol S) standard stock solution A (100mg/L, ethanol)
Accurately weigh 10mg (accurate to 0.1mg) bisphenol F (bisphenol S) standard, dissolve it in methanol and put it into a 100mL volumetric flask, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 3 months.
3.4.1.2 Bisphenol F (Bisphenol S) standard stock solution B (100mg/L, ethanol)
Accurately weigh 10mg (accurate to 0.1mg) bisphenol F (bisphenol S) standard, dissolve it in 10 acetone and put it into a 100mL volumetric flask, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 3 months.
3.4.2 Standard intermediate solution
3.4.2.1 Bisphenol F (Bisphenol S) standard intermediate solution A (10.0mg/L, ethanol)
Accurately pipette 10.0 mL bisphenol F (bisphenol S) standard stock solution A (3.4.1.1) into a 100 mL volumetric flask, scale with methanol, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 1 month.
3.4.2.2 Bisphenol F (Bisphenol S) standard intermediate solution B (10.0mg/L, isooctane)
Accurately pipette 10.0 mL bisphenol F (bisphenol S) standard stock solution B (3.4.1.2) into a 100 mL volumetric flask, scale with isooctane, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 1 month.
3.4.2.3 Bisphenol F (Bisphenol S) standard intermediate solution C (1.00mg/L, ethanol- water)
1 Scope
2 Principle
3 Reagents and materials
4 Apparatus
5 Analytical procedures
6 Expression of analysis results
7 Precision
8 Others
9 Principle
10 Reagents and materials
11 Apparatuses
12 Analytical procedures
13 Expression of analysis results
14 Precision
15 Others
Annex A Liquid chromatograph of bisphenol F and bisphenol S
Annex B LC-MS-MS method reference conditions
Annex C Total ion current chromatograph of bisphenol F and bisphenol S
Standard
GB 31604.54-2023 National food safety standard - Food contact materials and products - Determination of migration of bisphenol F and S (English Version)
Standard No.
GB 31604.54-2023
Status
valid
Language
English
File Format
PDF
Word Count
11500 words
Price(USD)
288.0
Implemented on
2024-9-6
Delivery
via email in 1 business day
Detail of GB 31604.54-2023
Standard No.
GB 31604.54-2023
English Name
National food safety standard - Food contact materials and products - Determination of migration of bisphenol F and S
GB 31604.54-2023 National food safety standard - Food contact materials and products - Determination of migration of bisphenol F and S
1 Scope
This standard specifies the determination of bisphenol F and bisphenol S migration in food contact materials and articles by LC method and LC-MS-MS method.
Method I - LC method applies to the determination of bisphenol F and bisphenol S migration in food contact plastic materials and articles, food contact paints and coatings, food contact paper and paperboard materials and food contact articles.
Method II - LC-MS-MS method applies to the determination of bisphenol F and bisphenol S migration in food contact materials and articles.
Method I LC method
2 Principle
Determine food contact materials and articles by LC method after migration test according to GB 31604.1 and GB 5009.156, inject the water-based, acidic and alcoholic food simulants directly after being filtered. Dry 95% (volume fraction) ethanol with nitrogen, scale with ethanol-water and inject the sample after filtering. Extract oil-like food simulants by methanol-water mixture, filter it and then inject. Dry the isooctane chemical alternative solvent with nitrogen, scale with methanol and water, filter it and then inject. Fix the quantity by external standard method.
3 Reagents and materials
Unless otherwise specified, all reagents used for this method are chromatographically pure, and the water is Class I water specified in GB/T 6682.
3.1 Reagents
3.1.1 Water-based, acid, alcoholic and oil-like food simulants and chemical alternative solvents: the reagents used comply with GB 5009.156.
3.1.2 n-hexane (C6H14)
3.1.3 Methanol (CH4O)
3.1.4 Acetonitrile (C2H3N)
3.1.5 Isooctane (C8H18)
3.1.3 Acetone (C3H6O)
3.1.7 Ethanol(C2H6O)
3.1.8 Corn oil: chemically pure, complying with GB 5009.156.
3.2 Preparation of reagents
3.2.1 Water-based, acidic and alcoholic, corn oil food simulants and chemical alternative solvents: prepared according to GB 5009.156.
3.2.2 Methanol-water mixture (1+1): measure 100mL ethanol and 100mL water, and mix well.
3.2.3 Ethanol-water mixture (1+1): measure 100mL ethanol and 100mL water, and mix well.
3.3 Standard
3.3.1 Bisphenol F (C13H12O2,CAS: 620-92-8): purity ≥99%, or standard certified by the state and granted a standard substance certificate.
3.3.2 Bisphenol S (C12H10O4, CAS: 80-09-1): purity ≥99%, or standard certified by the state and granted a standard substance certificate.
3.4 Preparation of standard solution
3.4.1 Standard stock solution
3.4.1.1 Bisphenol F (Bisphenol S) standard stock solution A (100mg/L, ethanol)
Accurately weigh 10mg (accurate to 0.1mg) bisphenol F (bisphenol S) standard, dissolve it in methanol and put it into a 100mL volumetric flask, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 3 months.
3.4.1.2 Bisphenol F (Bisphenol S) standard stock solution B (100mg/L, ethanol)
Accurately weigh 10mg (accurate to 0.1mg) bisphenol F (bisphenol S) standard, dissolve it in 10 acetone and put it into a 100mL volumetric flask, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 3 months.
3.4.2 Standard intermediate solution
3.4.2.1 Bisphenol F (Bisphenol S) standard intermediate solution A (10.0mg/L, ethanol)
Accurately pipette 10.0 mL bisphenol F (bisphenol S) standard stock solution A (3.4.1.1) into a 100 mL volumetric flask, scale with methanol, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 1 month.
3.4.2.2 Bisphenol F (Bisphenol S) standard intermediate solution B (10.0mg/L, isooctane)
Accurately pipette 10.0 mL bisphenol F (bisphenol S) standard stock solution B (3.4.1.2) into a 100 mL volumetric flask, scale with isooctane, and mix well. Transfer the solution to a brown standard solution stock bottle and store it in the refrigerator at 4℃ in the dark. The solution will be valid for 1 month.
3.4.2.3 Bisphenol F (Bisphenol S) standard intermediate solution C (1.00mg/L, ethanol- water)
Contents of GB 31604.54-2023
1 Scope
2 Principle
3 Reagents and materials
4 Apparatus
5 Analytical procedures
6 Expression of analysis results
7 Precision
8 Others
9 Principle
10 Reagents and materials
11 Apparatuses
12 Analytical procedures
13 Expression of analysis results
14 Precision
15 Others
Annex A Liquid chromatograph of bisphenol F and bisphenol S
Annex B LC-MS-MS method reference conditions
Annex C Total ion current chromatograph of bisphenol F and bisphenol S
