GB 31604.57-2023 National food safety standard - Food contact materials and products - Determination of migration of benzophenone substances (English Version)
GB 31604.57-2023 National food safety standard - Determination of migration of benzophenone substances in food contact materials and articles
1 Scope
This standard specifies the determination method of migration quantity of eight kinds of benzophenone substances in food contact materials and articles.
Method I - Liquid chromatography is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol, and chemical alternative solvents 95% (v/v) ethanol and isooctane.
Method II - Liquid chromatography - Tandem mass spectrometry is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol and olive oil, and chemical alternative solvents 95% (v/v) ethanol and isooctane.
Method I Liquid chromatography
2 Principle
Food contact materials and articles are subjected to migration test according to GB 31604.1 and GB 5009.156, and then detected by liquid chromatography. The food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol, and 50% (v/v) ethanol can be directly injected. The chemical alternative solvent of 95% (v/v) ethanol is diluted with water, filtered, and then injected. The chemical alternative solvent of isooctane is blown with nitrogen, redissolved in an aqueous methanol solution, filtered, and then injected. Quantification is carried out by the external standard method using peak area.
3 Reagents and materials
Unless otherwise stated, reagents used in this method are analytically pure, and the water is Grade I water as specified in GB/T 6682.
3.1 Reagents
3.1.1 Glacial acetic acid (CH3COOH).
3.1.2 Absolute ethanol (C2H5OH).
3.1.3 Isooctane (C8H18).
3.1.4 Methanol (CH3OH): chromatographically pure.
3.1.5 Dimethyl sulfoxide (C2H6OS).
3.2 Preparation of reagents
3.2.1 4% (v/v) acetic acid solution, 10% (v/v) ethanol solution, 20% (v/v) ethanol solution and 50% (v/v) ethanol solution are prepared according to GB 5009.156.
3.2.2 95% (v/v) ethanol solution: Mix absolute ethanol and water at a volume ratio of 95:5.
3.2.3 Aqueous methanol solution (7+3): Mix methanol and water at a volume ratio of 7:3.
3.3 Standards
3.3.1 (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone (C14H12O4, CAS No.: 131-53-3): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.2 2, 4-dihydroxybenzophenone (C13H10O3, CAS No.: 131-56-6): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.3 (2-hydroxy-4-methoxyphenyl) phenylketone (C14H12O3, CAS No.: 131-57-7): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.4 4, 4'-dihydroxybenzophenone (C13H10O3, CAS No.: 611-99-4): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
Foreword i
1 Scope
Method I Liquid chromatography
2 Principle
3 Reagents and materials
4 Apparatus
5 Analytical procedures
6 Expression of analysis results
7 Accuracy
8 Others
Method II Liquid chromatography-Tandem mass spectrometry
9 Principle
10 Reagents and materials
11 Apparatus
12 Analytical procedures
13 Expression of analysis results
14 Accuracy
15 Others
Annex A Liquid chromatograms for standard solutions of 8 kinds of benzophenones
Annex B Mass spectrometry reference conditions
Annex C Total ion current (TIC) chromatograms of 8 benzophenones by liquid chromatography-tandem mass spectrometry
Standard
GB 31604.57-2023 National food safety standard - Food contact materials and products - Determination of migration of benzophenone substances (English Version)
Standard No.
GB 31604.57-2023
Status
valid
Language
English
File Format
PDF
Word Count
11000 words
Price(USD)
290.0
Implemented on
2024-9-6
Delivery
via email in 1 business day
Detail of GB 31604.57-2023
Standard No.
GB 31604.57-2023
English Name
National food safety standard - Food contact materials and products - Determination of migration of benzophenone substances
GB 31604.57-2023 National food safety standard - Determination of migration of benzophenone substances in food contact materials and articles
1 Scope
This standard specifies the determination method of migration quantity of eight kinds of benzophenone substances in food contact materials and articles.
Method I - Liquid chromatography is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol, and chemical alternative solvents 95% (v/v) ethanol and isooctane.
Method II - Liquid chromatography - Tandem mass spectrometry is applicable to determination of the migration quantities of (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone, 2, 4-dihydroxybenzophenone, (2-hydroxy-4-methoxyphenyl) phenylketone, 4, 4'-dihydroxybenzophenone, 2-hydroxy-4-n-octyloxybenzophenone, 2-hydroxy-4-n-hexyloxybenzophenone, benzophenone and 4, 4'-difluorobenzophenone from plastics, paint and coating, rubber, and food contact materials and articles using ink in food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol and 50% (v/v) ethanol and olive oil, and chemical alternative solvents 95% (v/v) ethanol and isooctane.
Method I Liquid chromatography
2 Principle
Food contact materials and articles are subjected to migration test according to GB 31604.1 and GB 5009.156, and then detected by liquid chromatography. The food simulants of water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol, and 50% (v/v) ethanol can be directly injected. The chemical alternative solvent of 95% (v/v) ethanol is diluted with water, filtered, and then injected. The chemical alternative solvent of isooctane is blown with nitrogen, redissolved in an aqueous methanol solution, filtered, and then injected. Quantification is carried out by the external standard method using peak area.
3 Reagents and materials
Unless otherwise stated, reagents used in this method are analytically pure, and the water is Grade I water as specified in GB/T 6682.
3.1 Reagents
3.1.1 Glacial acetic acid (CH3COOH).
3.1.2 Absolute ethanol (C2H5OH).
3.1.3 Isooctane (C8H18).
3.1.4 Methanol (CH3OH): chromatographically pure.
3.1.5 Dimethyl sulfoxide (C2H6OS).
3.2 Preparation of reagents
3.2.1 4% (v/v) acetic acid solution, 10% (v/v) ethanol solution, 20% (v/v) ethanol solution and 50% (v/v) ethanol solution are prepared according to GB 5009.156.
3.2.2 95% (v/v) ethanol solution: Mix absolute ethanol and water at a volume ratio of 95:5.
3.2.3 Aqueous methanol solution (7+3): Mix methanol and water at a volume ratio of 7:3.
3.3 Standards
3.3.1 (2-hydroxy-4-methoxyphenyl) (2-hydroxyphenyl) ketone (C14H12O4, CAS No.: 131-53-3): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.2 2, 4-dihydroxybenzophenone (C13H10O3, CAS No.: 131-56-6): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.3 (2-hydroxy-4-methoxyphenyl) phenylketone (C14H12O3, CAS No.: 131-57-7): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
3.3.4 4, 4'-dihydroxybenzophenone (C13H10O3, CAS No.: 611-99-4): A standard substance with a purity greater than or equal to 98%, or certified by the state and granted with a certificate for standards.
Contents of GB 31604.57-2023
Foreword i
1 Scope
Method I Liquid chromatography
2 Principle
3 Reagents and materials
4 Apparatus
5 Analytical procedures
6 Expression of analysis results
7 Accuracy
8 Others
Method II Liquid chromatography-Tandem mass spectrometry
9 Principle
10 Reagents and materials
11 Apparatus
12 Analytical procedures
13 Expression of analysis results
14 Accuracy
15 Others
Annex A Liquid chromatograms for standard solutions of 8 kinds of benzophenones
Annex B Mass spectrometry reference conditions
Annex C Total ion current (TIC) chromatograms of 8 benzophenones by liquid chromatography-tandem mass spectrometry
