Standard No.:	GB 31604.63-2025
English Name:	National food safety standard- Food contact materials and products - Determination of migration of 4,4'- biphenol and 1,1'- sulfonyl bis (4-chlorobenzene)
Chinese Name:	食品安全国家标准 食品接触材料及制品?4,4’-联苯二酚和1,1’-磺酰基二（4-氯苯）迁移量的测定
Chinese Classification:	X09    Hygiene, safety and labor protection
Professional Classification:	GB    National Standard
Source Content Issued by:	National Health Commission of the People's Republic of China, State Administration for Market Regulation
Issued on:	2025-03-16
Implemented on:	2025-9-16
Status:	valid
Target Language:	English
File Format:	PDF
Word Count:	6000 words
Translation Price(USD):	180.0
Delivery:	via email in 1~3 business day

GB 31604.63-2025 National food safety standard- Food contact materials and products - Determination of migration of 4,4'- biphenol and 1,1'- sulfonyl bis (4-chlorobenzene) English, Anglais, Englisch, Inglés, えいご This is a draft translation for reference among interesting stakeholders. The finalized translation (passing through draft translation, self-check, revision and verification) will be delivered upon being ordered. National Standard of the People's Republic of China ‌GB 31604.21-2025 National Food Safety Standard - Food Contact Materials and Articles - Determination of migration of 4,4'- biphenol and 1,1'- sulfonyl bis (4-chlorobenzene) Issue date: 2025-09-02 Implementation date: 2026-03-02 Issued by the General Administration of Quality Supervision, Inspection and Quarantine of the People's Republic of China the National Health Commission of the People’s Republic of China ‌Contents‌ Foreword 1 Scope 2 Principle 3 Reagents and Materials 4 Instruments and Equipment 5 Analytical Procedure 6 Expression of Analytical Results 7 Precision 8 Others National Food Safety Standard Food Contact Materials and Articles Determination of migration of 4,4'- biphenol and 1,1'- sulfonyl bis (4-chlorobenzene) 1 Scope This standard specifies the method for determining the migration of 4,4'-diphenol and 1,1'-sulfonylbis(4-chlorophenyl) in food contact materials and articles. This standard applies to the determination of migration levels of 4,4'-dihydroxybenzene and 1,1'-sulfonyldi(4-chlorophenyl) in plastic and coated food contact materials and articles. 2 Principle After migration testing of food contact materials and articles, food simulants in water, 4% (v/v) acetic acid, 10% (v/v) ethanol, 20% (v/v) ethanol, and 50% (v/v) ethanol are filtered and directly injected; Chemical substitute solvents (95% ethanol, iso-octane) are nitrogen-flushed, redissolved in acetonitrile-water solutions, filtered, and injected. Corn oil food simulants are extracted with acetonitrile followed by solid-phase column extraction. Detection is performed by liquid chromatography with external standard quantification. Part I Determination of Migration Levels of 4,4'-Dibenzophenol and 1,1'-Sulfonylbis(4-chlorophenyl) in Water-Based Food Simulants and Chemical Substitute Solvents 3 Reagents and Materials Unless otherwise specified, reagents used in this method are analytical grade. Water complies with Grade 1 water as defined by GB/T 6682. 3.1 Reagents 3.1.1 Glacial acetic acid (C₂H₄O₂). 3.1.2 Anhydrous ethanol (C₂H₆O). 3.1.3 95% ethanol (C₂H₆O). 3.1.4 Isooctane (C₈H₁₈). 3.1.5 Methanol (CH₄O): Chromatography grade. 3.1.6 Acetonitrile (C₂H₃N): Chromatography grade. 3.1.7 Dimethyl sulfoxide (C₂H₆OS). 3.1.8 Acetone (C₃H₆O). 3.2 Reagent Preparation 3.2.1 Preparation of 4% acetic acid solution, 10% ethanol solution, 20% ethanol solution, and 50% ethanol solution shall follow GB 5009.156. 3.2.2 Acetonitrile-water solution (1+1): Mix acetonitrile and water uniformly in a 1:1 volume ratio. 3.3 Reference Standards 3.3.1 4,4'-Dihydroxybenzene (C₁₂H₁₀O₂, CAS No.: 92-88-6): Purity ≥98%, or a reference material/standard sample certified by a national authority and issued with a Certificate of Analysis. 3.3.2 1,1'-Sulfonylbis(4-chlorophenyl) (C₁₂H₈Cl₂O₂S, CAS No.: 80-07-9): Purity ≥98%, or a national certified reference material/standard sample granted a certificate of analysis. 3.4 Standard Solution Preparation 3.4.1 Standard Stock Solution (1000 mg/L) Accurately weigh 50 mg each of 4,4'-dihydroxybenzene and 1,1'-sulfonyldi(4-chlorophenyl) standard substances (accurate to 0.1 mg). Dissolve each in methanol and transfer to two 50 mL volumetric flasks. Dilute to the mark with methanol and mix thoroughly. Transfer the solutions to brown glass containers. Store tightly closed in the dark at 4°C. Shelf life: 6 months. 3.4.2 4,4'-Dihydroxybenzene Standard Intermediate Solution A (50 mg/L) Transfer 5.0 mL of the 4,4'-Dihydroxybenzene standard stock solution (1000 mg/L) to a 100 mL volumetric flask. Dilute to the mark with acetone, mix thoroughly to obtain 4,4'-Dihydroxybenzene Standard Intermediate Solution A with a mass concentration of 50.0 mg/L. Transfer the solution to a brown glass container, store tightly closed in the dark at 4°C, with a shelf life of 3 months. 3.4.3 Prepare a mixture of standard intermediate solution A (5 mg/L) Pipette 0.5 mL each of the 4,4'-Dihydroxybenzene and 1,1'-Sulfonylbis(4-chlorophenyl) standard stock solutions (1000 mg/L) into a 100 mL volumetric flask. Dilute to the mark with acetone, mix thoroughly, to obtain Mixed Standard Intermediate Solution A. with a mass concentration of 5.0 mg/L for each substance. Transfer the solution to a brown glass container, store it tightly closed at 4°C protected from light, and use within 3 months. 3.4.4 Standard Series Working Solutions 3.4.4.1 Standard Series Working Solutions (Applicable to Water, 4% Acetic Acid, 10% Ethanol, 20% Ethanol, 50% Ethanol Food Simulants) Pipette 50 μL, 100 μL, 200 μL, 400 μL, and 1000 μL of mixed standard intermediate solution A (5 mg/L) into five 10 mL volumetric flasks. Then pipette 200 μL, 400 μL, 1000 μL, 2000 μL of 4,4'-Dihydroxybenzene standard intermediate solution A (50 mg/L) into four 10 mL volumetric flasks. Dilute each to the mark with acetonitrile-water solution (1+1) and mixed thoroughly to obtain a series of 4,4'-dihydroxybenzene standard working solutions with concentrations of 0.025 mg/L, 0.050 mg/L, 0.10 mg/L, 0.20 mg/L, 0.50 mg/L, 1.0 mg/L, 2.0 mg/L, 5.0 mg/L, 10.0 mg/L. Prepare the 1,1'-sulfonylbis(4-chlorophenyl) standard series working solutions with concentrations of 0.025 mg/L, 0.050 mg/L, 0.10 mg/L, 0.20 mg/L, and 0.50 mg/L. Prepare fresh solutions as needed. 3.4.4.2 Standard Series Working Solutions (Applicable to Chemical Substitute Solvents) Pipette 50 μL, 100 μL, 200 μL, 400 μL, and 1000 μL of mixed standard intermediate solution A (5 mg/L) into five 10 mL volumetric flasks. Then add 200 μL, 400 μL, 1000 μL, and 2000 μL of 4,4'-Dihydroxybenzene standard intermediate solution A (50 mg/L) into four 10 mL volumetric flasks. Dilute each to the mark with the corresponding chemical substitute solvent (95% ethanol or iso-octane), and mixed thoroughly to obtain a series of 4,4'-dihydroxybenzene standard working solutions with concentrations of 0.025 mg/L, 0.050 mg/L, 0. 10 mg/L, 0.20 mg/L, 0.50 mg/L, 1.0 mg/L, 2.0 mg/L, 5.0 mg/L, 10.0 mg/L, 1, 1'-sulfonyl di(4-chlorophenyl) standard series working solutions have mass concentrations of 0.025 mg/L, 0.050 mg/L, 0.10 mg/L, 0.20 mg/L, 0.50 mg/L. Prepare fresh before use. Prior to instrument operation, process simultaneously with the chemical substitute solvent immersion solution according to 5.1.2.2. 3.5 Materials 3.5.1 Cartridge Filter: Equipped with hydrophilic polytetrafluoroethylene (PTFE) microporous membrane, pore size 0.45 μm. 4 Instruments and Equipment 4.1 High-Performance Liquid Chromatograph: Equipped with a UV detector or diode array detector. 4.2 Balance: Sensitivity of 0.1 mg. 4.3 Nitrogen Concentrator. 5 Analytical Procedure 5.1 Test Solution Preparation